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Scientist I/II, Multiplexed Editing

If interested and qualified, please include Requisition # 2018-321 in the subject line when emailing resume to: careers@crisprtx.com.

For more information on CRISPR Therapeutics, please click here.

Position Summary

We are seeking a talented molecular and cell biologist to lead multiplexed gene editing efforts to identify the next generation of transformative CRISPR/Cas9-based gene editing therapies.  Innovation, attention to detail, and the ability to work collaboratively and cross-functionally are all must-have characteristics for success in this role.

Responsibilities

  • Design and implement multiplexed gene editing strategies for next-generation CRISPR-based therapies,
  • Propose and test methods of CRISPR engineering for temporal control of CRISPR activity via gRNA and/or Cas9 modifications
  • Engineering and modifying primary human T-cells with CRISPR/Cas9 and downstream molecular and cellular testing
  • Assess off-target risk of multiplexed gene editing, particularly structural variants including chromosomal rearrangements between cut sites
  • Design, implement, and troubleshoot experiments, both independently and in collaboration with colleagues and cross-functional groups, to reach desired goals
  • Communicate research and development findings with internal and external partners
  • Assist supervisor in coordinating the day to day activities of associate scientists

Minimum Qualifications

  • Ph.D. degree with 5+ years of relevant experience in cell and molecular biology
  • Ability to work independently and successfully in a matrix environment, prioritize and manage multiple tasks simultaneously, integrate cross-functional issues and balance competing priorities effectively
  • Knowledge of molecular and cellular research techniques (qPCR, ddPCR, NGS library prep, Western blotting, RNAi, mammalian cell culture, etc.)

Preferred Qualifications

  • Experience with design of gRNA and/or Cas9 modifications to control activity
  • Knowledge of gene editing with CRISPR/Cas9, including targeting multiple genomic loci
  • Knowledge of DNA repair, including structural variants due to DNA breaks (including formation and detection)
  • Management experience with research associates
  • Ability to understand and make decisions / recommendations for high level strategy and tactical implementation of research efforts
  • A high degree of energy, accuracy and attention to detail, and a passion for creating transformative gene-based medicines to patients with serious diseases
  • Experience working in fast paced team environments (industry and start-up experience is a plus)

Competencies

  • Communication and Teamwork – The ability to work co-operatively with others; the genuine desire to be a part of a team and contribute to team and corporate goals. The ability to effectively express ideas in written and oral context with honesty and transparency.
  • Undaunted – Being fearless against hurdles and challenges. Able to focus on a goal or assignment with a positive attitude and without being distracted or side-tracked.  Having the end-goal in mind at all times.
  • Results Oriented – Drives issues and tasks to closure and gets the job done.
  • Entrepreneurial Spirit/Flexibility – An adventurous spirit, exhibiting ingenuity. A readiness in undertaking a task or project with considerable initiative and risk. The ability to adapt to working effectively within a variety of situations; adapts enthusiastically to organizational change and to changes in job demands.

If interested and qualified, please include Requisition # 2018-321 in the subject line when emailing resume to: careers@crisprtx.com.

For more information on CRISPR Therapeutics, please click here.