Sr. Research/ Principal Associate, Genomics Assays

Position Summary

We are seeking a Sr. Research Associate/Principal Research Associate to join an exciting, fast growing, and well-financed company to support development of novel gene editing therapies for serious diseases. This person will develop genomic-based non-clinical and clinical assays to support the CRISPR Therapeutics pipeline. The position requires enthusiasm, passion, attention to detail, and a desire to create new medicines for patients.

Responsibilities
  • Develop, optimize, and characterize high-quality (GLP/GMP-like) genomic assays and prepare SOPs for technology transfer to external collaborators
  • Efficiently perform method development and pre-qualification of genomic assays employing drug development phase appropriate strategies
  • Supporting multiple preclinical and clinical projects by transferring and qualifying assays and by providing technical expertise when needed
  • Planning, transfer and execution of critical assays, samples and reagents to CROs
  • Analysis and presentation of experimental data
  • Manage a portfolio of genomic assay development and transfer
  • Act as project manager for special departmental projects
  • Generate and analyze experimental data and present to key stakeholders
  • Maintain laboratory equipment, facilities, consumables, and materials
  • Maintain clear and complete records of study material and experimental results
  • Work cross-functionally with therapeutic, clinical and clinical operation groups
Minimum Qualifications
  • BS (5+ years) or MS (3+ years) in biology or related discipline,
  • Understanding of genomic assay protocols including NGS
  • Extensive experience operating instruments used in the genomics space, including those used for capillary electrophoresis and sequencing
  • Excellent organizational skills and oral and written communication skills
  • Ability to think strategically, manage time and workflow, and work independently as well as part of a results-oriented research team
  • Proficient in Excel and data analysis/visualization using tools such as GraphPad Prism (or similar).
  • Ability to travel, if required (less than 25%)
  • Prior experience working in an industry setting such as Biotech, Pharma or equivalent
Preferred Qualifications
  • 7+ years of experience working in a NGS laboratory and/or sequencing lab, with GLP/GCLP lab experience a plus
  • Understanding of gene editing tools (CRISPR, TALEN, or ZFN) as well as previous experience in gene editing
  • Prior experience in method optimization of genomic techniques in the context of preclinical and clinical level studies
  • Experience in drafting, editing and validating SOPs for use in GLP/GMP environments
Competencies
  • Collaborative Openness, One Team
  • Undaunted – Fearless, Can-do attitude
  • Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
  • Entrepreneurial Spirit – Proactive. Ownership mindset.

Crispr Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

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Requisition # 2018-357

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